题目：EngineeredTools for the Characterization and Manipulation of Endothelial Cells

时间：10月16日（周五）上午10:30

地点：光电工程学院342会议室

报告人：Dr. Du Yue（National University of Singapore）

主持人：彭争春 教授

Abstract

Engineered cellular systems open up new opportunities for probing cell functional mechanisms as well as systematically controlling cell behaviors for developing new treatments for human diseases. This talk will introduce our development of engineered toolsfor cellular characterization and manipulation with high-focalitymagnetic tweezers, atomic force microscopy (AFM), microfluidic chip processing, particle image velocimetry (PIV), and traction force microscopy (TFM). These tools enabled us to actively manipulate local rigidity of extracellular matrix (ECM) and to characterize endothelial cell behaviors such as the mechanical interactions with the ECM, cellular adhesion and migration under controlled experimental conditions. The work demonstrated a proof-of-concept feasibility of probing and manipulating cellsat the micro/nano-scale level of precision.

About the Speaker

Dr. Du Yue is currently a research fellow in the Department of Mechanical Engineering, National University of Singapore. She obtained her PhD degree from National University of Singapore, and her Master’s and Bachelor degree from Harbin Institute of Technology and Northeast Agricultural University, respectively. Dr. Du has conducted a wide spectrum of research on engineered cellular characterization and manipulation and robot/biomanipulator design, with fruitful outcomes in both fundamental and applied research. She has worked on the projects funded by Singapore-MIT Alliance for Research and Technology (SMART), Agency for Science, Technology and Research (A*STAR) and National Natural Science Foundation of China. She has published 10 technical articles in high quality, peer-reviewed journals and conference proceedings.